{"id":15431,"date":"2015-05-04T20:17:15","date_gmt":"2015-05-04T20:17:15","guid":{"rendered":"https:\/\/breastcancer.ca\/etude-de-numb-une-proteine-connue-pour-supprimer-le-cancer-du-sein\/"},"modified":"2015-05-04T20:17:15","modified_gmt":"2015-05-04T20:17:15","slug":"etude-de-numb-une-proteine-connue-pour-supprimer-le-cancer-du-sein","status":"publish","type":"post","link":"https:\/\/breastcancer.ca\/fr\/etude-de-numb-une-proteine-connue-pour-supprimer-le-cancer-du-sein\/","title":{"rendered":"\u00c9tude de Numb : une prot\u00e9ine connue pour supprimer le cancer du sein"},"content":{"rendered":"

Bonjour ! Je m’appelle Ran Wei et je suis doctorant au D\u00e9partement de biochimie de l’Universit\u00e9 Western, travaillant avec Shawn Li, PhD. <\/p>\n

\"\"<\/a>
Ran Wei, Dr Shawn Li et Xuguang Liu<\/figcaption><\/figure>\n

Notre laboratoire s’int\u00e9resse \u00e0 la d\u00e9couverte des voies impliqu\u00e9es dans le d\u00e9veloppement de diff\u00e9rents cancers, dont le cancer du sein. Certains changements dans ces voies sont intimement associ\u00e9s \u00e0 la progression du cancer. L’un de ces changements li\u00e9s aux tumeurs est la modification post-traductionnelle comme la m\u00e9thylation. Une modification post-traductionnelle (MPT) est un ajout \u00e0 une prot\u00e9ine apr\u00e8s sa fabrication. Nous d\u00e9veloppons actuellement de nouvelles th\u00e9rapies en ciblant ces MPT ou leurs enzymes modificatrices. <\/p>\n

L’un de mes sujets de recherche est le ciblage de la m\u00e9thylation de Numb. Numb est une prot\u00e9ine connue pour supprimer le cancer du sein, et la perte de l’expression de la prot\u00e9ine Numb est positivement corr\u00e9l\u00e9e \u00e0 l’agressivit\u00e9 tumorale et \u00e0 un mauvais pronostic. <\/p>\n

Notre \u00e9tude pr\u00e9c\u00e9dente r\u00e9v\u00e8le que la m\u00e9thylation de Numb par l’enzyme Set8 a un effet similaire \u00e0 la perte de Numb. Par cons\u00e9quent, il est concevable que l’inhibition de la m\u00e9thylation de Numb par un inhibiteur de Set8 pr\u00e9sente un grand potentiel th\u00e9rapeutique pour le traitement du cancer du sein. <\/p>\n

Actuellement, il n’existe aucun inhibiteur commercial pour Set8. Nous avons utilis\u00e9 des technologies de pointe telles que les micropuces peptidiques et la spectrom\u00e9trie de masse pour d\u00e9velopper un inhibiteur peptidique potentiel de Set8 appel\u00e9 PR9-G8. PR9-G8 a montr\u00e9 une inhibition significative de l’activit\u00e9 de Set8. Actuellement, nous testons les effets du peptide PR9-G8 sur plusieurs lign\u00e9es cellulaires diff\u00e9rentes de cancer du sein et tout effet sera ensuite test\u00e9 sur des mod\u00e8les de x\u00e9nogreffes de souris. <\/p>\n

J’ai pr\u00e9sent\u00e9 ce travail lors de la Journ\u00e9e de recherche et d’\u00e9ducation en oncologie de Western en 2013, o\u00f9 j’ai remport\u00e9 un prix pour ma pr\u00e9sentation par affiche.<\/p>\n

Merci \u00e0 BCSC pour votre soutien aux stagiaires !
\n– Ran Wei, <\/em>\u00e9tudiant chercheur
\n<\/em>Unit\u00e9 de recherche translationnelle sur le cancer du sein Pamela Greenaway-Kohlmeier, Centre des sciences de la sant\u00e9 de London<\/p>\n","protected":false},"excerpt":{"rendered":"

Bonjour ! Je m’appelle Ran Wei et je suis doctorant au D\u00e9partement de biochimie de l’Universit\u00e9 Western, travaillant avec Shawn Li, PhD. Notre laboratoire s’int\u00e9resse \u00e0 la d\u00e9couverte des voies impliqu\u00e9es dans le d\u00e9veloppement de diff\u00e9rents cancers, dont le cancer du sein. Certains changements dans ces voies sont intimement associ\u00e9s \u00e0 la progression du cancer. […]<\/p>\n","protected":false},"author":1,"featured_media":15433,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[514],"tags":[563,528,590,591,592,593,553,594,589,574,595],"class_list":["post-15431","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","tag-cancer-du-sein","tag-centre-des-sciences-de-la-sante-de-london","tag-departement-de-biochimie","tag-dr-shawn-li","tag-methylation-de-numb","tag-ran-wei","tag-recherche-sur-le-cancer-du-sein","tag-set8","tag-unite-de-recherche-translationnelle-sur-le-cancer-du-sein","tag-universite-western","tag-xuguang-liu"],"acf":[],"yoast_head":"\n\u00c9tude de Numb : une prot\u00e9ine connue pour supprimer le cancer du sein - Breast Cancer Canada<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/breastcancer.ca\/fr\/etude-de-numb-une-proteine-connue-pour-supprimer-le-cancer-du-sein\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c9tude de Numb : une prot\u00e9ine connue pour supprimer le cancer du sein - Breast Cancer Canada\" \/>\n<meta property=\"og:description\" content=\"Bonjour ! Je m’appelle Ran Wei et je suis doctorant au D\u00e9partement de biochimie de l’Universit\u00e9 Western, travaillant avec Shawn Li, PhD. Notre laboratoire s’int\u00e9resse \u00e0 la d\u00e9couverte des voies impliqu\u00e9es dans le d\u00e9veloppement de diff\u00e9rents cancers, dont le cancer du sein. Certains changements dans ces voies sont intimement associ\u00e9s \u00e0 la progression du cancer. 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